Synthesis, characterization, and evaluation of antioxidant and antimicrobial activity of three novel n-heteroaromatic hydrazonyl-thiazoles

(Thiazolyl-2-yl)hydrazones (THs) are a group of organic compounds containing both hydrazone and 1,3-thiazole pharmacophores present in many approved drugs. They have been investigated greatly recent years due to potent anticancer, antibacterial, antifungal, antituberculosis, anti-inflammatory, antiparasitic activities. In this study, one pyridine-based two quinoline-based, novel THs were synthesized characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR). The antimicrobial activity the was tested against five Gram-positive Gram-negative bacteria, as well three fungi. antioxidant capacity six antioxidative assays. results showed that quinoline-based more active bacteria fungi strains than compounds. All excellent comparable or greater used standards (vitamin C Trolox). Absorption, distribution, metabolism, excretion, toxicity (ADMET) parameters calculated in-silico. Results pointed promising good pharmacokinetics profiles compounds, especially 2-quinoline carboxaldehyde-based compound, which can be lead drug candidate.